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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually focused on the practical aspects of study design, including the recruitment process and consent, adherence, and the use of routinely available equipment.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for 슬롯 a pragmatic trial to be valid and reduce bias in results, is also necessary. However, too much heterogeneity can result in issues with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policymakers and practitioners to inform their decisions. They are also a good method of determining the causal relationship between an intervention and its results. However, they should not be used to substitute for the use of explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or 프라그마틱 정품인증 if they should serve as a complement to them. Schwartz and Lellouch1 made the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study which includes recruitment, design, delivery of the intervention and its follow-up.

There is a positive trend in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note, however, that the majority of these studies were conducted in primary-care settings.