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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically described by their focus on practical aspects of study design that include recruitment and consent, adherence and the use routinely available equipment.
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A pragmatic trial that uses various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for pragmatic trials to be valid and to reduce bias in the results is also essential. A high degree of heterogeneity, however can result in problems with the design of the trial.
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The purpose of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. Usually, they are ordered by policymakers and practitioners to help inform their decisions. They can also be a great method of determining the cause-effect relationship between an intervention and its outcomes. However, they should not be used as a substitute for explanatory studies.
The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can be used to replace explanation tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, 프라그마틱 슬롯 무료체험 무료체험 슬롯버프 [check out the post right here] which prove the validity of a clinical or physiological hypothesis and pragmatic trials that inform the practice and 프라그마틱 정품확인 policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study which includes the recruitment, design, and delivery of the intervention and follow-up.
There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.