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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are usually focused on the practical aspects of study design, such as the recruitment process and consent, adherence, and the use of standard equipment.

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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. However too much heterogeneity could result in problems with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are usually requested by policy makers and practitioners to aid in their decision-making. They also provide a useful way to identify the causal relationship between an intervention and its outcomes. They should not, however, be used to replace explanatory studies.

The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate a physiological or clinical hypothesis as well as pragmatic trials, which inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic research study, including the recruitment, design, and delivery of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note, however, 프라그마틱 데모 무료슬롯 (Https://iblog.Iup.edu) that the majority of these studies were conducted in primary-care settings.