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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically focused on the practical aspects of research design, like the recruitment and consent process in adherence, as well as the use of commonly available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and participants from various geographical areas. This type of heterogeneity, that is crucial for pragmatic trials to be valid and lessen the chance of bias, 프라그마틱 무료 슬롯 이미지 (Https://aiwins.wiki/Wiki/The_Reasons_Pragmatic_Demo_Is_Everyones_Desire_In_2024) is also necessary. A high degree of heterogeneity, however could cause issues with the trial design.

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The aim of pragmatic trials is to replicate real-life situations and achieve maximum validity externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They also provide a useful method of determining the causality between an intervention and its outcomes. They should, however, not be used to replace the need for explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.