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Pragmatic trials are those that are designed to inform the real-world practice of clinical. They are often described as focusing on practical aspects of study design which include the recruitment process and consent, adhering and the use of standard equipment.

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A pragmatic study that involves various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for practical trials to be valid and reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.

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The goal of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are typically commissioned by policymakers and practitioners in order to guide their decisions. They can also be a great method of determining the causal relationship between an intervention and its outcomes. They should, however, not, be used to replace explanatory studies.

The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a practical trial, including recruitment, design and delivery of the intervention, 프라그마틱 정품 확인법 as well as monitoring.

There is a growing increase in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority were conducted in primary-care settings.