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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described as a focus on the practical aspects of designing a study that include the recruitment process and consent, adhering and the use of standard equipment.

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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be valid, and it also reduces the chance of bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually commissioned by policymakers and practitioners to inform their decisions. They can also be used to determine the causal relationship between an intervention and its results. However, they should not, be used to replace the need for explanation studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and 프라그마틱 슬롯 조작 Lellouch1 suggested the distinction between explanatory trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, 프라그마틱 슬롯무료 무료 슬롯버프 (click the up coming internet site) which guide the practice and 프라그마틱 슬롯 policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study which includes the recruitment, design, and delivery of the intervention and follow-up.

There is a positive trend in the number of pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to keep in mind that the majority were conducted in primary care settings.