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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are often characterized by their focus on practical aspects of study design which include the recruitment process and consent, adhering and the use routinely available equipment.

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Pragmatic, a software company offers a range of casino games to online gambling platforms. Its iGaming software is used by top operators as well as land-based casinos. The company offers front-end tools for design, analysis, promotions, marketing and payment systems, as well as security, customer service and bug reporting. The company also offers a safe environment with high-quality graphics, gaming and security.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from different geographic areas. This kind of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. However excessive heterogeneity could cause issues with the design of the trial.

Pragmatic Play is one of the biggest players on the live casino market, provides an array of traditional table games like Blackjack and Roulette. The live studios of the company in Romania and Malta provide a genuine gambling experience for players and offer an extensive selection of virtual betting options. The company also has created numerous interactive game shows that make online gambling enjoyable. Some of these shows feature live hosts, whereas others are hosted by prominent personalities from the industry.

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Pragmatic Play, a new player in the field of online casinos, has gained recognition for its slot machines that are mobile-friendly. Their games are optimized for mobile phones, and run using HTML5 technology. They're also endorsed by trusted gaming authorities to ensure transparency and fairness. This is a positive sign for players, as it means that the games are checked and verified to ensure that the results of each round are random and unbiased.

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The majority of Pragmatic Play games are available for free, so you can test them before you decide to play for real money. These free games are designed to run on all kinds of devices including tablets, desktops and smartphones. You can play them anywhere you have an internet connection. They are easy-to-navigate. Some Pragmatic Play websites even let you test your luck while in motion by playing a test mode. This helps you become familiar with the game's rules and features before playing for real money.

Legality

Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. Its software can be used on mobile devices and in a variety of languages. It has established itself as one of the leading gaming platforms for casinos despite its relative youth. Wolves is one of its latest releases which is a five-reel slot machine with a hefty RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-world situations and have the highest external validity. Usually, they are commissioned by policymakers and practitioners to inform their decisions. They can also be used to determine the causality of an intervention and its effects. However, they should not be used to substitute for the use of explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis and pragmatic trials, which guide policy and practice decisions. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a pragmatic study which includes the recruitment process, the design and implementation of the intervention, as well as the follow-up.

There is an encouraging increase in the number pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more sensitive to the issue of pragmatics. It is important to keep in mind, however, that the majority were conducted in primary-care settings.