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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are often characterized by a focus on the practical aspects of research design, like the recruitment process and consent as well as adherence to the use of commonly available equipment.

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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for practical trials to be valid and reduces the chance of bias in the results. However too much heterogeneity could result in issues with the design of the trial.

Pragmatic Play Pragmatic Play, a major player on the live casino market offers a variety of classic table games like Blackjack and Roulette. The live studios of the company in Romania and Malta offer a real-life gaming experience for its customers, as well as a full suite of virtual betting options. The company also offers a variety of games that make online gambling more exciting and interactive. Some of these shows have live hosts, while others are hosted by famous personalities from the industry.

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Pragmatic Play is renowned for its top-notch games, and for offering an exceptional user experience. Its software is designed to work with mobile devices and supports different languages. Despite its relative youth it has established itself as a premier casino gaming platform. The latest releases include Wolves 5 reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They can also be used to determine the cause-effect relationship of an intervention and its effects. They should, however, not, be used to replace explanatory studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they are a complement to them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic research study, including the recruitment, design, and delivery of the intervention and its follow-up.

There is a growing trend in the number of pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatics. It is important to keep in mind, however, that the majority were conducted in primary-care settings.